The Departments of Physics, Dental Prosthodontics and Biomaterials, and Department of Oral and Maxillofacial Surgery at UAB propose an interdisciplinary program to evaluate nanocrystalline coatings for dental implants. We propose to test the hypothesis that the wear and bone fixation characteristics of TMJ (temporomandibular joint) implant devices can be significantly improved by manipulation of the nanostructure of diamond coatings (adhesion and wear) and hydroxyapatite coatings (fixation). Nanocrystalline diamond coatings with surface roughness of only 5-10 nm will be produced by microwave plasma chemical vapor deposition process with methane/hydrogen/nitrogen species. Our preliminary adhesion and toughness studies have shown no shear failure/loosening of diamond particles up to 150 kg indentation load. Nanocrystalline calcium phosphate (primarily hydroxyapatite) coatings will be deposited by pulsed laser deposition techniques onto the screws and device surfaces in contact with bone. Precise control of chemistry and structure of the thin coating should result in a more optimum surface for fixation with bone. Novel design strategies will be implemented for uniform coating over curved surfaces by rotation and translation of the implant in the activated plasma. Nanostructured -diamond and -hydroxyapatite can be interfaced on the same implant, provided diamond deposition at high temperature is done first followed by a low temperature deposition of hydroxyapatite using pulsed lasers. Nanoindentation studies will be carried out to measure the modulus and hardness of coatings as well as wear testing under simulated dental conditions. In vivo biocompatibility testing of nanostructured diamond and calcium phosphate ceramics will be carried out using standardized model systems, including injection of particulate debris, plus soft and hard tissue evaluations of particulates and implants. The in vivo part will be carried out in collaboration with an oral and maxillofacial clinician/surgeon at UAB, who actively participates in the area of TMJ surgical reconstruction.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
3R01DE013952-03S1
Application #
6802653
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Hunziker, Rosemarie
Project Start
2001-09-01
Project End
2004-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$50,000
Indirect Cost
Name
University of Alabama Birmingham
Department
Physics
Type
Schools of Arts and Sciences
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Kim, Hyunbin; Camata, Renato P; Chowdhury, Shafiul et al. (2010) In vitro dissolution and mechanical behavior of c-axis preferentially oriented hydroxyapatite thin films fabricated by pulsed laser deposition. Acta Biomater 6:3234-41
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Hill, Michael R; Catledge, Shane A; Konovalov, Valeriy et al. (2008) Preliminary tribological evaluation of nanostructured diamond coatings against ultra-high molecular weight polyethylene. J Biomed Mater Res B Appl Biomater 85:140-8
Kim, Hyunbin; Camata, Renato P; Lee, Sukbin et al. (2007) Crystallographic texture in pulsed laser deposited hydroxyapatite bioceramic coatings. Acta Mater 55:131-139
Chowdhury, S; Hillman, Damon A; Catledge, Shane A et al. (2006) Synthesis of ultrasmooth nanostructured diamond films by microwave plasma chemical vapor deposition using a He/H(2)/CH(4)/N(2) gas mixture. J Mater Res 21:2675-2682
Konovalov, Valery V; Melo, Andrew; Catledge, Shane A et al. (2006) Ultra-smooth nanostructured diamond films deposited from He/H2/CH4/N2 microwave plasmas. J Nanosci Nanotechnol 6:258-61

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