Abstract

Micropuncture experiments on distal convoluted tubules indicate that parathyroid hormone and cyclic AMP enhance calcium reabsorption in this nephron segment. Changes in colloid osmotic pressure in the vascular perfusate of isolated perfused rat kidneys led to parallel changes in absolute fluid reabsorption by pump perfused proximal tubular segments of such kidneys. Lowering of peritubular sodium concentration results in a reduced hydro-osmotic response of cortical collecting tubules. A similar maneuver in proximal convoluted tubules (isolated perfused proximal tubules) reduces net reabsorption of sodium and of water.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK011489-20
Application #
3224790
Study Section
General Medicine B Study Section (GMB)
Project Start
1978-07-01
Project End
1989-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
20
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Frindt, Gustavo; McNair, Tiffany; Dahlmann, Anke et al. (2002) Epithelial Na channels and short-term renal response to salt deprivation. Am J Physiol Renal Physiol 283:F717-26
Weinstein, A M; Windhager, E E (2001) The paracellular shunt of proximal tubule. J Membr Biol 184:241-5
Frindt, G; Masilamani, S; Knepper, M A et al. (2001) Activation of epithelial Na channels during short-term Na deprivation. Am J Physiol Renal Physiol 280:F112-8
Mennitt, P A; Frindt, G; Silver, R B et al. (2000) Potassium restriction downregulates ROMK expression in rat kidney. Am J Physiol Renal Physiol 278:F916-24
Silver, R B; Choe, H; Frindt, G (1998) Low-NaCl diet increases H-K-ATPase in intercalated cells from rat cortical collecting duct. Am J Physiol 275:F94-102
Palmer, L G; Sackin, H; Frindt, G (1998) Regulation of Na+ channels by luminal Na+ in rat cortical collecting tubule. J Physiol 509 ( Pt 1):151-62
Echevarria, M; Windhager, E E; Frindt, G (1996) Selectivity of the renal collecting duct water channel aquaporin-3. J Biol Chem 271:25079-82
Mulders, S M; Olde Weghuis, D; van Boxtel, J A et al. (1996) Localization of the human gene for aquaporin 3 (AQP3) to chromosome 9, region p21-->p12, using fluorescent in situ hybridization. Cytogenet Cell Genet 72:303-5
Frindt, G; Palmer, L G; Windhager, E E (1996) Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C. Am J Physiol 270:F371-6
Ecelbarger, C A; Terris, J; Frindt, G et al. (1995) Aquaporin-3 water channel localization and regulation in rat kidney. Am J Physiol 269:F663-72

Showing the most recent 10 out of 20 publications