Intestinal Protein Metabolism and Function

Alpers, David H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 2R01DK014038-27
• Application #: 2136827
• Study Section: Special Emphasis Panel (ZRG4-GMA-1 (02))
• Project Start: 1977-12-01
• Project End: 2000-11-30
• Budget Start: 1996-04-01
• Budget End: 1996-11-30
• Support Year: 27
• Fiscal Year: 1996

Institution

• Name: Washington University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 062761671
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Mahmood, Akhtar; Engle, Michael J; Alpers, David H (2002) Secreted intestinal surfactant-like particles interact with cell membranes and extracellular matrix proteins in rats. J Physiol 542:237-44

Mahmood, A; Engle, M J; Hultgren, S J et al. (2000) Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli. Biochim Biophys Acta 1523:49-55

Xie, Q; Alpers, D H (2000) The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Physiol Genomics 3:8-Jan

Goetz, G S; Mahmood, A; Hultgren, S J et al. (1999) Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes. Infect Immun 67:6161-3

Eliakim, R; Goetz, G S; Rubio, S et al. (1997) Isolation and characterization of surfactant-like particles in rat and human colon. Am J Physiol 272:G425-34

Zhang, Y; Shao, J S; Xie, Q M et al. (1996) Immunolocalization of alkaline phosphatase and surfactant-like particle proteins in rat duodenum during fat absorption. Gastroenterology 110:478-88

Eliakim, R; Alpers, D H; Oren, R et al. (1996) Abundance of surfactant-like particles reflects mucosal integrity in patients with peptic ulcer disease. Gut 39:353-9

Dieckgraefe, B K; Santoro, S A; Alpers, D H (1996) Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis. Gastroenterology 110:58-71

Alpers, D H; Zhang, Y; Ahnen, D J (1995) Synthesis and parallel secretion of rat intestinal alkaline phosphatase and a surfactant-like particle protein. Am J Physiol 268:E1205-14

Yamagishi, F; Becich, M J; Evans, B A et al. (1994) Clearance of surfactant-like particle proteins from circulation in rats. Am J Physiol 266:G596-605