Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK017631-13S1
Application #
3225808
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1977-06-01
Project End
1988-07-31
Budget Start
1988-02-01
Budget End
1988-07-31
Support Year
13
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Orava, M; Zhao, X F; Leiter, E et al. (1994) Structure and chromosomal location of the gene encoding mouse corticosteroid-binding globulin: strain differences in coding sequence and steroid-binding activity. Gene 144:259-64
Leiter, E H; Chapman, H D (1994) Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93:2007-13
Leiter, E H; Chapman, H D; Falany, C N (1991) Synergism of obesity genes with hepatic steroid sulfotransferases to mediate diabetes in mice. Diabetes 40:1360-3
Prochazka, M; Leiter, E H (1991) Effect of androgen insensitivity on diabetogenesis in db/db male mice with testicular feminization (Tfm). Horm Metab Res 23:149-54
Hurbain-Kosmath, I; Berault, A; Noel, N et al. (1990) Gonadotropes in a novel rat pituitary tumor cell line, RC-4B/C. Establishment and partial characterization of the cell line. In Vitro Cell Dev Biol 26:431-40
Leiter, E H; Hamaguchi, K (1990) Viruses and diabetes: diabetogenic role for endogenous retroviruses in NOD mice? J Autoimmun 3 Suppl 1:31-40
Leiter, E H; Chapman, H D; Coleman, D L (1989) The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 124:912-22
Leiter, E H (1989) The genetics of diabetes susceptibility in mice. FASEB J 3:2231-41
Leiter, E H (1988) Control of spontaneous glucose intolerance, hyperinsulinemia, and islet hyperplasia in nonobese C3H.SW male mice by Y-linked locus and adrenal gland. Metabolism 37:689-96
Leiter, E H; Premdas, F; Harrison, D E et al. (1988) Aging and glucose homeostasis in C57BL/6J male mice. FASEB J 2:2807-11

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