A series of experiments is proposed to characterize the lateral hypothalamic (LH) lesion induced reduction in the body protein and lipid tissue masses. The specific tissues sacrificed in reducing body protein, and the role growth hormone may play in these changes will be assessed. The possibility that altered capacities for fat oxidation contribute to lesion-induced body lipid changes will also be examined. In a final series of experiments, the activity of brown adipose tissue and the norepinephrine turnover rate in visceral tissues will be used to assess lesion-induced changes in sympathetic nervous system activity during the acute hypermetabolic phase and during the chronic stage of stable, but reduced, body mass.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK019944-29
Application #
2137410
Study Section
Biopsychology Study Section (BPO)
Program Officer
Yanovski, Susan Z
Project Start
1977-04-01
Project End
1999-06-30
Budget Start
1995-07-01
Budget End
1999-06-30
Support Year
29
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Psychiatry
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715