The response elicited by any given taste is not determined by the taste itself. The animal's experience with the taste and its postingestive effects, and it's metabolic state when it encounters a taste are factos that contribute to responses to taste. The particular response elicited by a taste derives from the neural integration of these 3 factors. One of the principal aims of this proposal is to determine the sites within the caudal brainstem (CBS) that integrate taste and internal state. Our experiments with chronic decerebrate rats and fourth ventricular infusions in intact rats demonstrate that taste and metabolic state information is integrated within the CBS. Another aim of the proposed experiments is to determine the nature of the metabolic state feedback that is integrated with taste to affect behavior. A variety of techniques including: intronal infusion of a sucrose concentration series, vagal deafferentation, surgical interference with the digestive tract and pontine and medullary gustatory nucleus lesions are used for these purposes. The long term goal of these experiments is to define the capacity of several neural levels of the rat brain to modify ingestive consummatory responses as a function of physiological and experiential factors and in so doing to examine whether a hierarchical hypothesis of ingestive control will help decipher the organization of a motivated and regulated system such as energy homeostasis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK021397-13
Application #
3226939
Study Section
Biopsychology Study Section (BPO)
Project Start
1983-07-01
Project End
1991-02-28
Budget Start
1990-03-01
Budget End
1991-02-28
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gerth, Ashlynn I; Alhadeff, Amber L; Grill, Harvey J et al. (2017) Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain Res 1655:252-260
Kanoski, Scott E; Grill, Harvey J (2017) Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms. Biol Psychiatry 81:748-756
Ong, Zhi Yi; Liu, Jing-Jing; Pang, Zhiping P et al. (2017) Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling. Neuropsychopharmacology 42:2387-2397
Alhadeff, Amber L; Holland, Ruby A; Zheng, Huiyuan et al. (2017) Excitatory Hindbrain-Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss. J Neurosci 37:362-370
Ong, Zhi Yi; Bongiorno, Diana M; Hernando, Mary Ann et al. (2017) Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats. Endocrinology 158:2826-2836
Alhadeff, Amber L; Golub, Danielle; Hayes, Matthew R et al. (2015) Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor. Am J Physiol Endocrinol Metab 309:E759-66
Kanoski, S E; Ong, Z Y; Fortin, S M et al. (2015) Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms. Diabetes Obes Metab 17:285-93
Swick, Jennifer C; Alhadeff, Amber L; Grill, Harvey J et al. (2015) Parabrachial Nucleus Contributions to Glucagon-Like Peptide-1 Receptor Agonist-Induced Hypophagia. Neuropsychopharmacology 40:2001-14
Müller, T D; Nogueiras, R; Andermann, M L et al. (2015) Ghrelin. Mol Metab 4:437-60
Ong, Zhi Yi; Alhadeff, Amber L; Grill, Harvey J (2015) Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing. Am J Physiol Regul Integr Comp Physiol 308:R800-6

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