Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK021404-06S1
Application #
3226956
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1979-09-30
Project End
1987-07-31
Budget Start
1986-12-01
Budget End
1987-07-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
039318308
City
Providence
State
RI
Country
United States
Zip Code
02906
Morris, D J; Souness, G W; Brem, A S et al. (2000) Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues. Kidney Int 57:1370-3
Morris, D J; Latif, S A; Rokaw, M D et al. (1998) A second enzyme protecting mineralocorticoid receptors from glucocorticoid occupancy. Am J Physiol 274:C1245-52
Latif, S A; Sheff, M F; Ribeiro, C E et al. (1997) Selective inhibition of sheep kidney 11 beta-hydroxysteroid dehydrogenase isoform 2 activity by 5 alpha-reduced (but not 5 beta) derivatives of adrenocorticosteroids. Steroids 62:230-7
Morris, D J; Souness, G W (1996) Endogenous 11 beta-hydroxysteroid dehydrogenase inhibitors and their role in glucocorticoid Na+ retention and hypertension. Endocr Res 22:793-801
Souness, G W; Morris, D J (1996) 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension 27:421-5
Souness, G W; Latif, S A; Laurenzo, J L et al. (1995) 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat. Endocrinology 136:1809-12
Morris, D J (1995) The role of steroid metabolism in protective and specificity conferring mechanisms of mineralocorticoid action. Vitam Horm 50:461-85
Souness, G W; Myles, K; Morris, D J (1994) Other physiological considerations of protective mechanisms of mineralocorticoid action. Steroids 59:142-7
Latif, S A; Hartman, L R; Souness, G W et al. (1994) Possible endogenous regulators of steroid inactivating enzymes and glucocorticoid-induced Na+ retention. Steroids 59:352-6
Morris, D J (1993) Liquorice: new insights into mineralocorticoid and glucocorticoid hypertension. R I Med 76:251-4

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