During the perinatal period, nutrition (i.e., composition of food) undergoes substantial changes (placental nutrition; milk, solid food). During this period, functions of the gastrointestinal tract exhibit corresponding changes; the mechanisms responsible for these changes are not yet understood. To contribute to elucidation of these problems, in the proposed experiments we will explore the following closely related areas: a) To characterize the reactivity to hormones, especially thyroid hormones and EGF, and adaptability to variation in carbohydrate intake of the microvillar disaccharidases during various periods of life, i.e., fetal, suckling, weaning, and adult life, and consequently in aged animals. b) To evaluate the effect of early perinatal manipulations (precocious maturation) induced by hormones or by a sudden change in diet such as occurring during the premature weaning on the adaptability of carbohydrases in adult and aged rats. c) Since hormones are present in milk and their physiological role in most cases is not yet understood, to evaluate the handling, i.e., digestion, retention and absorption of hormones present in milk by the gastrointestinal tract of the sucklings. The hormones that we have chosen to study are: ACTH, TSH, T3 and EGF. The need for these studies is further stressed by the fact that neonates fed no breast milk lose access to these and other hormones. The questions to be answered are: a) does the handling of hormones by the gastrointestinal tract change postnatally; or b) has the oral delivery of these hormones a functional significance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK027624-07
Application #
3228394
Study Section
(GCN)
Project Start
1980-01-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722
Shinohara, H; Williams, C; Koldovsky, O (1995) The use of poly R-478 as a marker to determine gastric emptying and intestinal propulsive motility in suckling rats. Physiol Res 44:281-6
Kong, W Y; Koldovsky, O; Rao, R K (1992) Appearance of exogenous epidermal growth factor in liver, bile, and intestinal lumen of suckling rats. Gastroenterology 102:661-7
Samulitis-dos Santos, B K; Goda, T; Koldovskyyy, O (1992) Dietary-induced increases of disaccharidase activities in rat jejunum. Br J Nutr 67:267-78
Grimes, J; Schaudies, P; Davis, D et al. (1992) Effect of short-term fasting/refeeding on epidermal growth factor content in the gastrointestinal tract of suckling rats. Proc Soc Exp Biol Med 199:75-80
Pollack, P F; Koldovskyyy, O; Nishioka, K (1992) Polyamines in human and rat milk and in infant formulas. Am J Clin Nutr 56:371-5
Koldovsky, O; Bedrick, A; Rao, R (1991) Role of milk-borne prostaglandins and epidermal growth factor for the suckling mammal. J Am Coll Nutr 10:17-23
Rao, R K (1991) Biologically active peptides in the gastrointestinal lumen. Life Sci 48:1685-704
Jiang, Q; Koldovsky, O; Bedrick, A et al. (1991) Bombesin differentially affects gastric emptying in suckling, weanling and adult rats. J Pharmacol Exp Ther 257:603-7
Rao, R K; Koldovsky, O; Grimes, J et al. (1991) Regional differences in gastrointestinal processing and absorption of epidermal growth factor in suckling rats. Am J Physiol 261:G790-8
Koldovsky, O; Britton, J; Grimes, J et al. (1991) Milk-borne epidermal growth factor (EGF) and its processing in developing gastrointestinal tract. Endocr Regul 25:58-62

Showing the most recent 10 out of 21 publications