We propose the continuation of a controlled, prospective study of the effects of plasmapheresis on the short-term and long-term courses of patients with severe forms of lupus glomerulonephritis. Plasmapheresis (plasma exchange) is a costly but unproven therapy in this disease. The continuation of this clinical trial of 125 patients followed for up to 6 years is proposed, the primary endpoint being mortality or renal failure. The Biostatistical Coordinating Center provides support for this collaborative trial in the study design (procedures, forms, randomization), execution (data processing support, editing, updating corrections, monitoring performance of clinics, patient safety data monitoring) and final statistical analysis and publications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK027769-06
Application #
3228475
Study Section
(SRC)
Project Start
1981-04-01
Project End
1988-06-30
Budget Start
1986-04-01
Budget End
1988-06-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052