Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK028015-11A4
Application #
2138081
Study Section
Special Emphasis Panel (ZRG2-END (01))
Project Start
1981-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Physiology
Type
Schools of Dentistry
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Costello, Leslie C; Franklin, Renty B (2012) Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity. Expert Rev Anticancer Ther 12:121-8
Costello, L C; Franklin, R B; Feng, Pei (2005) Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer. Mitochondrion 5:143-53
Costello, L C; Franklin, R B (2002) Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Horm Metab Res 34:417-24
Costello, L C; Franklin, R B (2000) The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy. Oncology 59:269-82
Costello, L C; Liu, Y; Zou, J et al. (2000) The pyruvate dehydrogenase E1 alpha gene is testosterone and prolactin regulated in prostate epithelial cells. Endocr Res 26:23-39
Liang, J Y; Liu, Y Y; Zou, J et al. (1999) Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate 40:200-7
Costello, L C; Franklin, R B; Narayan, P (1999) Citrate in the diagnosis of prostate cancer. Prostate 38:237-45
Costello, L C; Liu, Y; Zou, J et al. (1999) Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone. J Biol Chem 274:17499-504
Costello, L C; Franklin, R B (1998) Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer. Prostate 35:285-96
Costello, L C; Franklin, R B (1997) Citrate metabolism of normal and malignant prostate epithelial cells. Urology 50:3-12

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