Abstract

Sixty to 80 orthotopic liver transplantations in humans are planned for the year beginning with 1982, slightly more than half of the cases being in adults. For these patients a variety of improvements from that offered in the past are planned including better immunosuppression, refinements of the technical procedure of transplantation, study of the metabolic events following liver replacement, assessment of the growth and development of children, delineation of the neuropsychiatric changes following transplantation, assessment of the new pattern of infectious disease which is emerging under therapy with cyclosporin A and steroids, accurate assessment of the function of the homografted livers and further studies of inborn errors of metabolism. Animal work is planned to improve the preservation techniques of liver homografts, to evaluate new programs of immunosuppression for potential clinical use, and to examine the largely abandoned procedure of auxiliary liver transplantation for potential use in patients with acute liver failure or in patients whose portal vein has thrombosed and who cannot be treated with liver replacement.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK029961-07
Application #
3229163
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1981-01-01
Project End
1987-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Gandhi, Chandrashekhar R; Murase, Noriko; Starzl, Thomas E (2010) Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells. J Cell Physiol 222:365-73
Starzl, Thomas E; Fung, John J (2010) Themes of liver transplantation. Hepatology 51:1869-84
Shapiro, Ron; Basu, Amit; Tan, Henkie P et al. (2009) Kidney after nonrenal transplantation-the impact of alemtuzumab induction. Transplantation 88:799-802
Starzl, Thomas E; Barker, Clyde (2009) The origin of clinical organ transplantation revisited. JAMA 301:2041-3
Marsh, James W; Gray, Edward; Ness, Roberta et al. (2009) Complications of right lobe living donor liver transplantation. J Hepatol 51:715-24
Starzl, Thomas E (2008) Immunosuppressive therapy and tolerance of organ allografts. N Engl J Med 358:407-11
Thirunavukkarasu, Chinnasamy; Wang, Lian Fu; Harvey, Stephen A K et al. (2008) Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J Hepatol 48:578-88
Toyokawa, Hideyoshi; Nakao, Atsunori; Bailey, Robert J et al. (2008) Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl 14:346-57
Shapiro, Ron; Zeevi, Adriana; Basu, Amit et al. (2008) Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibody. Transplantation 85:1125-32
Starzl, Thomas E (2007) Acquired immunologic tolerance: with particular reference to transplantation. Immunol Res 38:6-41

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