Abstract

The proposed project will investigate the appetite for sugar, polysaccharide, and starch in laboratory rats. In particular, the project will follow-up our recent discovery that rats have a taste and avid appetite for starch-derived polysacchardes, and will overeat and become obese when given access to polysaccharide solutions.
The specific aims of the project are (I) to compare the gustatory and behavioral responses of rats to sugars, polysacharides and starch: (II) determine the ontological development of polysaccharide appetite; (III) determine the functional significance of the rats' different carbohydrate tastes; (IV) determine the role of taste and postingestive factors in the long-term preferences for carbohydrates; and (V) determine the influence of diet form and macronutrient composition on carbohydrate appetite and obesity. This research, which involves the fields of sensory physiology, psychobiology, and nutrition, will provide new information on the interaction of taste and nutrition in the control of food intake and body weight.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK031135-05
Application #
3229899
Study Section
Biopsychology Study Section (BPO)
Project Start
1984-07-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Brooklyn College
Department
Type
Schools of Arts and Sciences
DUNS #
620127691
City
New York
State
NY
Country
United States
Zip Code
11210

  Publications

Sclafani, Anthony; Vural, Austin S; Ackroff, Karen (2018) Profound differences in fat versus carbohydrate preferences in CAST/EiJ and C57BL/6J mice: Role of fat taste. Physiol Behav 194:348-355
Sclafani, Anthony (2018) From appetite setpoint to appetition: 50years of ingestive behavior research. Physiol Behav 192:210-217
Spector, Alan C; le Roux, Carel W; Munger, Steven D et al. (2017) Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling. JPEN J Parenter Enteral Nutr 41:113-124
Sclafani, Anthony; Ackroff, Karen (2017) Flavor preferences conditioned by nutritive and non-nutritive sweeteners in mice. Physiol Behav 173:188-199
Sclafani, Anthony; Vural, Austin S; Ackroff, Karen (2017) CAST/EiJ and C57BL/6J Mice Differ in Their Oral and Postoral Attraction to Glucose and Fructose. Chem Senses 42:259-267
Glendinning, John I; Frim, Yonina G; Hochman, Ayelet et al. (2017) Glucose elicits cephalic-phase insulin release in mice by activating KATP channels in taste cells. Am J Physiol Regul Integr Comp Physiol 312:R597-R610
Ackroff, Karen; Sclafani, Anthony (2016) Flavor Preferences Conditioned by Dietary Glutamate. Adv Nutr 7:845S-52S
Sclafani, Anthony; Adamantidis, Antoine; Ackroff, Karen (2016) MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice. Physiol Behav 163:239-244
Sclafani, Anthony (2016) Bypassing Intestinal Sugar Enhancement of Sweet Appetite. Cell Metab 23:3-4
Kraft, Tamar T; Huang, Donald; Lolier, Melanie et al. (2016) BALB/c and SWR inbred mice differ in post-oral fructose appetition as revealed by sugar versus non-nutritive sweetener tests. Physiol Behav 153:64-9

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