Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK032329-12
Application #
2138799
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1983-12-01
Project End
1997-04-30
Budget Start
1995-08-01
Budget End
1997-04-30
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Chapman, A; Stewart, S J; Nepom, G T et al. (1996) CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles. J Immunol 157:4771-80
Thomas, J W (1993) V region diversity in human anti-insulin antibodies. Preferential use of a VHIII gene subset. J Immunol 150:1375-82
Miller, G; Nepom, G T; Reich, M B et al. (1993) Autoreactive T cells from a type I diabetic recognize multiple class II products. Hum Immunol 36:219-26
Tanner, J J; Nell, L J; McCammon, J A (1992) Anti-insulin antibody structure and conformation. II. Molecular dynamics with explicit solvent. Biopolymers 32:23-32
Thomas, J W (1992) Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene. Eur J Immunol 22:2445-8
Nell, L J; McCammon, J A; Subramaniam, S (1992) Anti-insulin antibody structure and conformation. I. Molecular modeling and mechanics of an insulin antibody. Biopolymers 32:11-21
Ewulonu, U K; Nell, L J; Thomas, J W (1990) VH and VL gene usage by murine IgG antibodies that bind autologous insulin. J Immunol 144:3091-8
Miller, G G; Hoy, J F; Thomas, J W (1989) Insulin B chain functions as an effective competitor of antigen presentation via peptide homologies present in the thymus. J Exp Med 169:2251-6
Nell, L J; Hulbert, C; Thomas, J W (1989) Human insulin autoantibody fine specificity and H and L chain use. J Immunol 142:3063-9
Miller, G G; Hoy, J F; Nell, L J et al. (1988) Antigen processing and the human T cell receptor repertoire for insulin. J Immunol 141:3293-8

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