Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034642-09
Application #
2139356
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-08-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Minchenko, A; Caro, J (2000) Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsive element. Mol Cell Biochem 208:53-62
Srinivas, V; Zhu, X; Salceda, S et al. (1998) Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing. J Biol Chem 273:18019-22
Salceda, S; Beck, I; Srinivas, V et al. (1997) Complex role of protein phosphorylation in gene activation by hypoxia. Kidney Int 51:556-9
Salceda, S; Caro, J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-7
Salceda, S; Beck, I; Caro, J (1996) Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 334:389-94
Minchenko, A; Bauer, T; Salceda, S et al. (1994) Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 71:374-9
Minchenko, A; Salceda, S; Bauer, T et al. (1994) Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell Mol Biol Res 40:35-9
Schuster, S J; Caro, J (1993) Erythropoietin: physiologic basis for clinical applications. Vox Sang 65:169-79
Beck, I; Weinmann, R; Caro, J (1993) Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. Blood 82:704-11
Beck, I; Ramirez, S; Weinmann, R et al. (1991) Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 266:15563-6

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