Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036588-11
Application #
2139838
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1985-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Neubrand, Michael W; Carey, Martin C; Laue, Thomas M (2015) Influence of Phosphatidylcholine and Calcium on Self-Association and Bile Salt Mixed Micellar Binding of the Natural Bile Pigment, Bilirubin Ditaurate. Biochemistry 54:6783-95
Woods, Stephanie E; Leonard, Monika R; Hayden, Joshua A et al. (2015) Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous ""black"" pigment gallstone formation in germfree Swiss Webster mice. Am J Physiol Gastrointest Liver Physiol 308:G335-49
Neubrand, Michael W; Carey, Martin C; Laue, Thomas M (2015) Self-assembly of aqueous bilirubin ditaurate, a natural conjugated bile pigment, to contraposing enantiomeric dimers and M(-) and P(+) tetramers and their selective hydrophilic disaggregation by monomers and micelles of bile salts. Biochemistry 54:1542-57
Berman, Marvin D; Carey, Martin C (2015) Metastable and equilibrium phase diagrams of unconjugated bilirubin IX? as functions of pH in model bile systems: Implications for pigment gallstone formation. Am J Physiol Gastrointest Liver Physiol 308:G42-55
Wang, David Q-H; Carey, Martin C (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review. World J Gastroenterol 20:9952-75
Lavoie, B; Nausch, B; Zane, E A et al. (2012) Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease. Neurogastroenterol Motil 24:e313-24
Zhang, Ji; Handy, Diane E; Wang, Yufang et al. (2011) Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice. Hepatology 54:697-706
Freudenberg, Folke; Leonard, Monika R; Liu, Shou-An et al. (2010) Pathophysiological preconditions promoting mixed ""black"" pigment plus cholesterol gallstones in a DeltaF508 mouse model of cystic fibrosis. Am J Physiol Gastrointest Liver Physiol 299:G205-14
Wang, David Q-H; Cohen, David E; Carey, Martin C (2009) Biliary lipids and cholesterol gallstone disease. J Lipid Res 50 Suppl:S406-11
Biddinger, Sudha B; Haas, Joel T; Yu, Bian B et al. (2008) Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 14:778-82

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