Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036796-04
Application #
3235265
Study Section
General Medicine B Study Section (GMB)
Project Start
1985-07-01
Project End
1992-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Pollak, M R; Chou, Y H; Marx, S J et al. (1994) Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. J Clin Invest 93:1108-12
Katz, C L; Butters, R R; Chen, C J et al. (1992) Structure-function relationships for the effects of various aminoglycoside antibiotics on dispersed bovine parathyroid cells. Endocrinology 131:903-10
Brown, E M; Butters, R; Katz, C et al. (1992) A comparison of the effects of concanavalin-A and tetradecanoylphorbol acetate on the modulation of parathyroid function by extracellular calcium and neomycin in dispersed bovine parathyroid cells. Endocrinology 130:3143-51
Kifor, O; Kifor, I; Brown, E M (1992) Effects of high extracellular calcium concentrations on phosphoinositide turnover and inositol phosphate metabolism in dispersed bovine parathyroid cells. J Bone Miner Res 7:1327-36
Mathias, R S; Brown, E M (1991) Divalent cations modulate PTH-dependent 3',5'-cyclic adenosine monophosphate production in renal proximal tubular cells. Endocrinology 128:3005-12
Brown, E M; Butters, R; Katz, C et al. (1991) Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology 128:3047-54
Brown, E M; Katz, C; Butters, R et al. (1991) Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. J Bone Miner Res 6:1217-25
Gundberg, C M; Grant, F D; Conlin, P R et al. (1991) Acute changes in serum osteocalcin during induced hypocalcemia in humans. J Clin Endocrinol Metab 72:438-43
Brown, E M (1991) Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol Rev 71:371-411
Chen, C J; Brown, E M (1990) The diltiazem analog TA-3090 mimics the actions of high extracellular Ca2+ on parathyroid function in dispersed bovine parathyroid cells. J Bone Miner Res 5:581-7

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