Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK037319-05S1
Application #
3236185
Study Section
General Medicine B Study Section (GMB)
Project Start
1987-04-01
Project End
1995-09-29
Budget Start
1994-05-01
Budget End
1994-09-29
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Weinman, E J; Minkoff, C; Shenolikar, S (2000) Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol 279:F393-9
Weinman, E J; Steplock, D; Donowitz, M et al. (2000) NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry 39:6123-9
Zizak, M; Lamprecht, G; Steplock, D et al. (1999) cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. J Biol Chem 274:24753-8
Bernardo, A A; Kear, F T; Santos, A V et al. (1999) Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor. J Clin Invest 104:195-201
Weinman, E J; Steplock, D; Lamprecht, G et al. (1999) Regulation of the Na/H exchanger regulatory factor in OK cells. Miner Electrolyte Metab 25:135-42
Minkoff, C; Shenolikar, S; Weinman, E J (1999) Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr Opin Nephrol Hypertens 8:603-8
Weinman, E J; Steplock, D; Zhang, X et al. (1999) Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. Biochim Biophys Acta 1447:71-6
Weinman, E J; Steplock, D; Tate, K et al. (1998) Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). J Clin Invest 101:2199-206
Lamprecht, G; Weinman, E J; Yun, C H (1998) The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem 273:29972-8
Weinman, E J; Chamras, H (1996) Reconstitution of human red blood cell Na/H and Na/Na exchange transport. Am J Med Sci 312:47-53

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