Abstract

The objective of the proposed research is to gain a better understanding of the role the gut peptide, peptide YY (PYY), plays in the regulation of enteric and extraenteric physiology.
The specific aims of the research proposal are: 1. To characterize the mechanisms (i.e., neural or endocrine) involved in oral meal-stimulated release of peptide YY (PYY). 2. To characterize the mechanisms involved in the stimulation of adrenal epinephrine and cortisol secretion by PYY. 3. To study the mechanism by which PYY can modulate neurally-stimulated release of pancreatic insulin and gastric acid secretion. 4. To investigate the effect of PYY neutralization on the secretory responses of the stomach and of the exocrine pancreas. It is hoped that the above research will contribute to our understanding of the role of PYY in normal gut physiology as well as in pathologicaAl circumstances.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037406-02
Application #
3236294
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1988-09-20
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Guan, D; Rivard, N; Morisset, J et al. (1993) Effects of peptide YY on the growth of the pancreas and intestine. Endocrinology 132:219-23
Zhang, T; Gomez, G; Yanaihara, N et al. (1993) Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY. Am J Physiol 264:E933-7
Zhang, T; Brubaker, P L; Thompson, J C et al. (1993) Characterization of peptide-YY release in response to intracolonic infusion of amino acids. Endocrinology 132:553-7
Clave, P; Lluis, F; Thompson, J C et al. (1992) Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system. Biol Signals 1:40-5
Yoshinaga, K; Mochizuki, T; Yanaihara, N et al. (1992) Structural requirements of peptide YY for biological activity at enteric sites. Am J Physiol 263:G695-701
Zhang, T; Sumi, S; Thompson, J C et al. (1992) Release of peptide-YY from the dog pancreas. Endocrinology 130:2025-30
Lluis, F; Gomez, G; Greeley Jr, G H et al. (1992) Inhibitory action of peptide YY on pancreatic secretion is independent of secretin. Biol Signals 1:88-93
Hill, F L; Zhang, T; Gomez, G et al. (1991) Peptide YY, a new gut hormone (a mini-review). Steroids 56:77-82
Ishizuka, J; Tatemoto, K; Cohn, D V et al. (1991) Effects of pancreastatin and chromogranin A on insulin release stimulated by various insulinotropic agents. Regul Pept 34:25-32
Izukura, M; Hashimoto, T; Gomez, G et al. (1991) Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs. Pancreas 6:427-32

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