Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK038772-01
Application #
3238273
Study Section
Endocrinology Study Section (END)
Project Start
1986-08-01
Project End
1987-03-31
Budget Start
1986-08-01
Budget End
1987-03-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Leonard, J L; Leonard, D M; Safran, M et al. (1999) The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat. Endocrinology 140:2206-15
Shen, Q; Wu, R; Leonard, J L et al. (1998) Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem 273:5443-6
Leonard, J L; Farwell, A P (1997) Thyroid hormone-regulated actin polymerization in brain. Thyroid 7:147-51
Safran, M; Farwell, A P; Leonard, J L (1996) Catalytic activity of type II iodothyronine 5'-deiodinase polypeptide is dependent upon a cyclic AMP activation factor. J Biol Chem 271:16363-8
Leonard, J L; Leonard, D M; Shen, Q et al. (1996) Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem 61:410-9
Farwell, A P; Safran, M; Dubord, S et al. (1996) Degradation and recycling of the substrate-binding subunit of type II iodothyronine 5'-deiodinase in astrocytes. J Biol Chem 271:16369-74
Farwell, A P; Tranter, M P; Leonard, J L (1995) Thyroxine-dependent regulation of integrin-laminin interactions in astrocytes. Endocrinology 136:3909-15
Shen, Q; Leonard, J L; Newburger, P E (1995) Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA 1:519-25
Leonard, J L; Farwell, A P; Yen, P M et al. (1994) Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. Endocrinology 135:548-55
Bick, T; Frick, G P; Leonard, D et al. (1994) Overexpression of the short form of the growth hormone receptor in 3T3-L1 mouse preadipocytes. Proc Soc Exp Biol Med 206:185-9

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