Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK039532-08
Application #
2140951
Study Section
Physiology Study Section (PHY)
Project Start
1989-01-15
Project End
1998-12-31
Budget Start
1996-02-27
Budget End
1996-12-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Vijayakumar, S; Takito, J; Hikita, C et al. (1999) Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation. J Cell Biol 144:1057-67
Hikita, C; Takito, J; Vijayakumar, S et al. (1999) Only multimeric hensin located in the extracellular matrix can induce apical endocytosis and reverse the polarity of intercalated cells. J Biol Chem 274:17671-6
Takito, J; Yan, L; Ma, J et al. (1999) Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am J Physiol 277:F277-89
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Imundo, L; Barasch, J; Prince, A et al. (1995) Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc Natl Acad Sci U S A 92:3019-23
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Landry, D; Sullivan, S; Nicolaides, M et al. (1993) Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes. J Biol Chem 268:14948-55
Herzlinger, D; Koseki, C; Mikawa, T et al. (1992) Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction. Development 114:565-72

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