Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041557-08
Application #
2141811
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1988-09-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Cario, E; Gerken, G; Podolsky, D K (2007) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132:1359-74
Hisamatsu, Tadakazu; Suzuki, Manabu; Podolsky, Daniel K (2003) Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells. J Biol Chem 278:32962-8
Beck, Paul L; Rosenberg, Ian M; Xavier, Ramnik J et al. (2003) Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 162:597-608
Cario, Elke; Brown, Dennis; McKee, Mary et al. (2002) Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol 160:165-73
Cario, E; Gerken, G; Podolsky, D K (2002) ""For whom the bell tolls!"" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogens. Z Gastroenterol 40:983-90
Goke, M N; Cook, J R; Kunert, K S et al. (2001) Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res 264:337-44
Nishiyama, R; Sakaguchi, T; Kinugasa, T et al. (2001) Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem 276:35571-80
Cario, E; Podolsky, D K (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68:7010-7
Podolsky, D K (2000) Review article: healing after inflammatory injury--coordination of a regulatory peptide network. Aliment Pharmacol Ther 14 Suppl 1:87-93
Cario, E; Rosenberg, I M; Brandwein, S L et al. (2000) Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol 164:966-72

Showing the most recent 10 out of 47 publications