Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041572-07
Application #
2141820
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1989-05-20
Project End
1997-12-31
Budget Start
1995-05-01
Budget End
1997-12-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Ramsay, R R; Gandour, R D (1999) Selective modulation of carnitine long-chain acyltransferase activities. Kinetics, inhibitors, and active sites of COT and CPT-II. Adv Exp Med Biol 466:103-9
Nic a'Bhaird, N; Yankovskaya, V; Ramsay, R R (1998) Active sites residues of beef liver carnitine octanoyltransferase (COT) and carnitine palmitoyltransferase (CPT-II). Biochem J 330 ( Pt 2):1029-36
Cronin, C N (1997) cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitine. Eur J Biochem 247:1029-37
Nic a'Bhaird, N; Ramsay, R R (1995) The active site histidine of carnitine acyltransferases. Biochem Soc Trans 23:490S
Ramsay, R R (1994) Carnitine and its role in acyl group metabolism. Essays Biochem 28:47-61
Ramsay, R R; Arduini, A (1993) The carnitine acyltransferases and their role in modulating acyl-CoA pools. Arch Biochem Biophys 302:307-14
Gandour, R D; Leung, O T; Greway, A T et al. (1993) (+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransferase-I in intact mitochondria. J Med Chem 36:237-42
Brady, P S; Ramsay, R R; Brady, L J (1993) Regulation of the long-chain carnitine acyltransferases. FASEB J 7:1039-44
Nic a' Bhaird, N; Kumaravel, G; Gandour, R D et al. (1993) Comparison of the active sites of the purified carnitine acyltransferases from peroxisomes and mitochondria by using a reaction-intermediate analogue. Biochem J 294 ( Pt 3):645-51
Reznick, A Z; Kagan, V E; Ramsey, R et al. (1992) Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. Arch Biochem Biophys 296:394-401

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