Leukocyte Glutathione Peroxidase Expression

Newburger, Peter E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK041625-04
• Application #: 3242424
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1989-08-01
• Project End: 1994-07-31
• Budget Start: 1992-08-01
• Budget End: 1993-07-31
• Support Year: 4
• Fiscal Year: 1992

Institution

• Name: University of Massachusetts Medical School Worcester
• Type: Schools of Medicine
• DUNS #: 660735098
• City: Worcester
• State: MA
• Country: United States
• Zip Code: 01655

Publications

Wu, R; Shen, Q; Newburger, P E (2000) Recognition and binding of the human selenocysteine insertion sequence by nucleolin. J Cell Biochem 77:507-16

Shen, Q; Wu, R; Leonard, J L et al. (1998) Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem 273:5443-6

Rae, J; Newburger, P E; Dinauer, M C et al. (1998) X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet 62:1320-31

Leonard, J L; Leonard, D M; Shen, Q et al. (1996) Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem 61:410-9

Shen, Q; McQuilkin, P A; Newburger, P E (1995) RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. J Biol Chem 270:30448-52

Shen, Q; Townes, P L; Padden, C et al. (1994) An in-frame trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability. Genomics 23:292-4

Newburger, P E; Skalnik, D G; Hopkins, P J et al. (1994) Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558. J Clin Invest 94:1205-11

Shen, Q; Chu, F F; Newburger, P E (1993) Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem 268:11463-9

Baker, R D; Baker, S S; LaRosa, K et al. (1993) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B. Arch Biochem Biophys 304:53-7

Chada, S; Le Beau, M M; Casey, L et al. (1990) Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6:268-71