Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041625-04
Application #
3242424
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1989-08-01
Project End
1994-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Wu, R; Shen, Q; Newburger, P E (2000) Recognition and binding of the human selenocysteine insertion sequence by nucleolin. J Cell Biochem 77:507-16
Shen, Q; Wu, R; Leonard, J L et al. (1998) Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem 273:5443-6
Rae, J; Newburger, P E; Dinauer, M C et al. (1998) X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet 62:1320-31
Leonard, J L; Leonard, D M; Shen, Q et al. (1996) Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem 61:410-9
Shen, Q; McQuilkin, P A; Newburger, P E (1995) RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. J Biol Chem 270:30448-52
Shen, Q; Townes, P L; Padden, C et al. (1994) An in-frame trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability. Genomics 23:292-4
Newburger, P E; Skalnik, D G; Hopkins, P J et al. (1994) Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558. J Clin Invest 94:1205-11
Shen, Q; Chu, F F; Newburger, P E (1993) Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem 268:11463-9
Baker, R D; Baker, S S; LaRosa, K et al. (1993) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B. Arch Biochem Biophys 304:53-7
Chada, S; Le Beau, M M; Casey, L et al. (1990) Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6:268-71

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