Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK042015-05
Application #
2142037
Study Section
Special Emphasis Panel (ZRG7-SSS-8 (06))
Project Start
1992-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Chen, T; Friedman, K A; Lei, I et al. (2000) In situ assembled mass-transport controlling micromembranes and their application in implanted amperometric glucose sensors. Anal Chem 72:3757-63
Freeland, A C; Bonnecaze, R T (1999) Inference of blood glucose concentrations from subcutaneous glucose concentrations: applications to glucose biosensors. Ann Biomed Eng 27:525-37
Wagner, J G; Schmidtke, D W; Quinn, C P et al. (1998) Continuous amperometric monitoring of glucose in a brittle diabetic chimpanzee with a miniature subcutaneous electrode. Proc Natl Acad Sci U S A 95:6379-82
Ishikawa, M; Schmidtke, D W; Raskin, P et al. (1998) Initial evaluation of a 290-microm diameter subcutaneous glucose sensor: glucose monitoring with a biocompatible, flexible-wire, enzyme-based amperometric microsensor in diabetic and nondiabetic humans. J Diabetes Complications 12:295-301
Schmidtke, D W; Freeland, A C; Heller, A et al. (1998) Measurement and modeling of the transient difference between blood and subcutaneous glucose concentrations in the rat after injection of insulin. Proc Natl Acad Sci U S A 95:294-9
Schmidtke, D W; Heller, A (1998) Accuracy of the one-point in vivo calibration of ""wired"" glucose oxidase electrodes implanted in jugular veins of rats in periods of rapid rise and decline of the glucose concentration. Anal Chem 70:2149-55
Quinn, C A; Connor, R E; Heller, A (1997) Biocompatible, glucose-permeable hydrogel for in situ coating of implantable biosensors. Biomaterials 18:1665-70
Schmidtke, D W; Pishko, M V; Quinn, C P et al. (1996) Statistics for critical clinical decision making based on readings of pairs of implanted sensors. Anal Chem 68:2845-9
Csoregi, E; Schmidtke, D W; Heller, A (1995) Design and optimization of a selective subcutaneously implantable glucose electrode based on ""wired"" glucose oxidase. Anal Chem 67:1240-4
Quinn, C P; Pathak, C P; Heller, A et al. (1995) Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors. Biomaterials 16:389-96

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