Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043354-04A2
Application #
2142944
Study Section
Metabolism Study Section (MET)
Project Start
1991-07-15
Project End
2000-05-31
Budget Start
1996-06-15
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gao, Zhiyong; Young, Robert A; Li, Guizhu et al. (2003) Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Endocrinology 144:1949-57
Gao, Zhiyong; Young, Robert A; Trucco, Matteo M et al. (2002) Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis. Biochem J 368:397-404
Westerlund, Johanna; Wolf, Bryan A; Bergsten, Peter (2002) Glucose-dependent promotion of insulin release from mouse pancreatic islets by the insulin-mimetic compound L-783,281. Diabetes 51 Suppl 1:S50-2
Zhu, Yuan; Xu, Gang; Patel, Arun et al. (2002) Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80:144-50
Major, C D; Wolf, B A (2001) Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction. Diabetes 50:2721-8
Gao, Z; Reavey-Cantwell, J; Young, R A et al. (2000) Synaptotagmin III/VII isoforms mediate Ca2+-induced insulin secretion in pancreatic islet beta -cells. J Biol Chem 275:36079-85
Xu, G G; Gao, Z Y; Borge Jr, P D et al. (2000) Insulin regulation of beta-cell function involves a feedback loop on SERCA gene expression, Ca(2+) homeostasis, and insulin expression and secretion. Biochemistry 39:14912-9
Xu, G G; Gao, Z Y; Borge Jr, P D et al. (1999) Insulin receptor substrate 1-induced inhibition of endoplasmic reticulum Ca2+ uptake in beta-cells. Autocrine regulation of intracellular ca2+ homeostasis and insulin secretion. J Biol Chem 274:18067-74
Gao, Z Y; Li, G; Najafi, H et al. (1999) Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes 48:1535-42
Major, C D; Gao, Z Y; Wolf, B A (1999) Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: role in cytokine-induced beta-cell death. Diabetes 48:1372-80

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