Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043711-05
Application #
2143195
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1992-05-01
Project End
1997-11-30
Budget Start
1996-05-01
Budget End
1997-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Krieger, N R; Fathman, C G; Shaw, M K et al. (2000) Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+ T cells in vitro and in vivo. Transplantation 69:605-9
Krieger, N R; Yuh, D; McIntyre, W B et al. (1998) Prolongation of cardiac graft survival with anti-CD4Ig plus hCTLA4Ig in primates. J Surg Res 76:174-8
Yin, D P; Sankary, H N; Talor-Edwards, C et al. (1998) Anti-CD4 therapy in combined heart-kidney, heart-liver, and heart-small bowel allotransplants in high-responder rats. Transplantation 66:1-5
Krieger, N R; Fathman, C G (1997) The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection. J Heart Lung Transplant 16:263-7
Krieger, N R; Ito, H; Fathman, C G (1997) Rat pancreatic islet and skin xenograft survival in CD4 and CD8 knockout mice. J Autoimmun 10:309-15
Yin, D P; Sankary, H N; Williams, J et al. (1996) Induction of tolerance to small bowel allografts in high-responder rats by combining anti-CD4 with CTLA4Ig. Transplantation 62:1537-9
Krieger, N R; Yin, D P; Fathman, C G (1996) CD4+ but not CD8+ cells are essential for allorejection. J Exp Med 184:2013-8
Yin, D; Fathman, C G (1995) Induction of tolerance to heart allografts in high responder rats by combining anti-CD4 with CTLA4Ig. J Immunol 155:1655-9
Yin, D; Fathman, C G (1995) Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats. Transpl Immunol 3:258-64
Charlton, B; Meltzer, J; Fathman, C G (1994) CD4-positive/heat-stable antigen-positive thymocytes cause graft-versus-host disease across non-major histocompatibility complex incompatibilities. Eur J Immunol 24:1706-9

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