Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043883-07
Application #
2143373
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Kelavkar, Uddhav; Wang, Susheng; Badr, Kamal (2002) KU 70/80 lupus autoantigen is the transcription factor induced by interleukins (IL)-13 and -4 leading to induction of 15-lipoxygenase (15-LO) in human cells. Adv Exp Med Biol 507:469-81
Kelavkar, Uddhav; Cohen, Cynthia; Eling, Thomas et al. (2002) 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. Adv Exp Med Biol 507:133-45
Kelavkar, Uddhav; Wang, Susheng; Badr, Kamal (2002) Divergence in intracellular signaling between interleukin-4 (IL-4) and IL-13 in human cells localizes to monomeric/dimeric expression of a transcription factor, the lupus autoantigen 70/80, induced by both cytokines. Adv Exp Med Biol 507:483-9
Kelavkar, U P; Wang, S; Badr, K F (2000) Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells. Genes Immun 1:237-50
Montero, A; Nassar, G M; Uda, S et al. (2000) Reciprocal regulation of LTA(4) hydrolase expression in human monocytes by gamma-interferon and interleukins 4 and 13: potential relevance to leukotriene regulation in glomerular disease. Exp Nephrol 8:258-65
Kelavkar, U P; Cohen, C; Kamitani, H et al. (2000) Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. Carcinogenesis 21:1777-87
Kelavkar, U P; Badr, K F (1999) Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene. Proc Natl Acad Sci U S A 96:4378-83
Munger, K A; Montero, A; Fukunaga, M et al. (1999) Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis. Proc Natl Acad Sci U S A 96:13375-80
Kelavkar, U; Wang, S; Montero, A et al. (1999) Identification and characterization of an enhancer sequence in the promoter region of human 15-lipoxygenase (15-LO) gene. Adv Exp Med Biol 469:67-74
Kelavkar, U; Wang, S; Montero, A et al. (1998) Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. Mol Biol Rep 25:173-82

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