Regulation of Cholesterol 7 Alpha Hydroxylase

Gil, Gregorio

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 7R01DK044218-06
• Application #: 2454684
• Study Section: Metabolism Study Section (MET)
• Project Start: 1991-08-01
• Project End: 1999-08-31
• Budget Start: 1997-04-01
• Budget End: 1997-08-31
• Support Year: 6
• Fiscal Year: 1997

Institution

• Name: Virginia Commonwealth University
• Department: Physiology
• Type: Schools of Medicine
• City: Richmond
• State: VA
• Country: United States
• Zip Code: 23298

Publications

del Castillo-Olivares, Antonio; Gil, Gregorio (2002) Differential effects of sterol regulatory binding proteins 1 and 2 on sterol 12 alpha-hydroxylase. SREBP-2 suppresses the sterol 12 alpha-hydroxylase promoter. J Biol Chem 277:6750-7

del Castillo-Olivares, A; Gil, G (2001) Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism. Nucleic Acids Res 29:4035-42

del Castillo-Olivares, A; Gil, G (2000) Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription. Nucleic Acids Res 28:3587-93

del Castillo-Olivares, A; Gil, G (2000) Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. J Biol Chem 275:17793-9

Ramirez, M I; Karaoglu, D; Haro, D et al. (1994) Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice. Mol Cell Biol 14:2809-21