This application requests continuation of the large population-based registry of insulin-dependent diabetes mellitus (IDDM) among African-American and Hispanic children in Chicago. The Registry project includes on average 49 African-American cases and 20 Hispanic incident cases per year. This represents more than three times the number of African-origin cases than in any other registry worldwide, and the largest number of Hispanic cases in the continental US. The investigators will use the Registry to investigate two questions of immediate relevance, as follow. 1. Ethnic differences in the natural history of IDDM: Recent attention has focused on the possibility that some young people initially diagnosed with IDDM actually have a variant form of diabetes. To date, no population-based data are available on the spectrum of diabetic disease in U.S. youth. Considering the high risk of NIDDM among both African-American and Hispanics, there may well be unique genetic and/or pathophysiologic processes at work in insulin-treated minority children. The investigators hypothesize that clinically atypical disease will be described in a substantial proportion (5-15%) of insulin-treated minority patients, and that it can be distinguished from autoimmune diabetes on the basis of family history, onset characteristics, and genetic markers. 2. IDDM outcomes among minorities: The investigators recently demonstrated that the case-fatality rate for IDDM in Chicago is nine times greater among African-American than non-Hispanic white patients through age 24, and there is some evidence of disparities in morbidity as well. They hypothesize that, controlled for duration, the rates of early signs of developing complications in registered minority patients will significantly exceed those reported elsewhere among non-Hispanic white patients. They will investigate whether the mortality rate among African-American patients exceeds that among Hispanic patients in Chicago, and if mortality among both African-American and Hispanic patients exceed published rates elsewhere. They will accomplish the following specific tasks: 1) continue the incidence registry of IDDM among minority children in the City of Chicago; 2) determine the prevalence of atypical diabetes among these insulin-treated, youth onset patients; 3) construct a score to predict the subsequent clinical course of atypical diabetes in young minority patients; and 4) describe the natural history of diabetes complications and mortality in minority young people with IDDM.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK044752-10
Application #
6610310
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Akolkar, Beena
Project Start
1992-09-30
Project End
2003-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
10
Fiscal Year
2000
Total Cost
$130,366
Indirect Cost
Name
University of Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Sobotka, Sarah A; Danielson, Kirstie K; Drum, Melinda L et al. (2014) Maternal body mass index (BMI) is independently associated with the control of diabetes mellitus in young patients. Pediatr Nurs 40:187-94
Estrada, Carmela L; Danielson, Kirstie K; Drum, Melinda L et al. (2012) Insufficient sleep in young patients with diabetes and their families. Biol Res Nurs 14:48-54
Lipton, Rebecca B; Drum, Melinda; Greeley, Siri Atma W et al. (2011) HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes. Pediatr Diabetes 12:388-95
Lipton, Rebecca B; Drum, Melinda L; Danielson, Kirstie K et al. (2011) Onset features and subsequent clinical evolution of childhood diabetes over several years. Pediatr Diabetes 12:326-34
Kersey, Margaret; Lipton, Rebecca; Quinn, Michael T et al. (2010) Overweight in Latino preschoolers: do parental health beliefs matter? Am J Health Behav 34:340-8
Grigsby-Toussaint, Diana S; Lipton, Rebecca; Chavez, Noel et al. (2010) Neighborhood socioeconomic change and diabetes risk: findings from the Chicago childhood diabetes registry. Diabetes Care 33:1065-8
Danielson, Kirstie K; Drum, Melinda L; Estrada, Carmela L et al. (2010) Racial and ethnic differences in an estimated measure of insulin resistance among individuals with type 1 diabetes. Diabetes Care 33:614-9
Rosenfield, Robert L; Lipton, Rebecca B; Drum, Melinda L (2009) Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics 123:84-8
Kumaraguru, Janani; Flanagan, Sarah E; Greeley, Siri Atma W et al. (2009) Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes Care 32:1428-30
Estrada, Carmela L; Danielson, Kirstie K; Drum, Melinda L et al. (2009) Hospitalization subsequent to diagnosis in young patients with diabetes in Chicago, Illinois. Pediatrics 124:926-34

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