Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045123-05
Application #
2144365
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1992-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Gardner-Stephen, Dione; Heydel, Jean-Marie; Goyal, Amit et al. (2004) Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metab Dispos 32:340-7
Antonio, Laurence; Xu, Jing; Little, Joanna M et al. (2003) Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7. Arch Biochem Biophys 411:251-61
Radominska-Pandya, Anna; Chen, Guangping (2002) Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta. Biochemistry 41:4883-90
Radominska-Pandya, A; Chen, G; Samokyszyn, V M et al. (2001) Application of photoaffinity labeling with [(3)H] all trans- and 9-cis-retinoic acids for characterization of cellular retinoic acid--binding proteins I and II. Protein Sci 10:200-11
Jude, A R; Little, J M; Czernik, P J et al. (2001) Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved. Arch Biochem Biophys 389:176-86
Jude, A R; Little, J M; Freeman, J P et al. (2000) Linoleic acid diols are novel substrates for human UDP-glucuronosyltransferases. Arch Biochem Biophys 380:294-302
Samokyszyn, V M; Gall, W E; Zawada, G et al. (2000) 4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. J Biol Chem 275:6908-14
Little, J M; Lester, R; Kuipers, F et al. (1999) Variability of human hepatic UDP-glucuronosyltransferase activity. Acta Biochim Pol 46:351-63
Senay, C; Battaglia, E; Chen, G et al. (1999) Photoaffinity labeling of the aglycon binding site of the recombinant human liver UDP-glucuronosyltransferase UGT1A6 with 7-azido-4-methylcoumarin. Arch Biochem Biophys 368:75-84
Gall, W E; Zawada, G; Mojarrabi, B et al. (1999) Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7. J Steroid Biochem Mol Biol 70:101-8

Showing the most recent 10 out of 18 publications