Activation of CFTR Variants Pharmacologically

Drumm, Mitchell L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 7R01DK045965-02
• Application #: 3247504
• Study Section: Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
• Project Start: 1992-09-30
• Project End: 1995-09-29
• Budget Start: 1993-01-01
• Budget End: 1993-09-29
• Support Year: 2
• Fiscal Year: 1992

Institution

• Name: Case Western Reserve University
• Type: Schools of Medicine
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Ma, J; Zhao, J; Drumm, M L et al. (1997) Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel. J Biol Chem 272:28133-41

Ma, J; Tasch, J E; Tao, T et al. (1996) Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein. J Biol Chem 271:7351-6

Tao, T; Xie, J; Drumm, M L et al. (1996) Slow conversions among subconductance states of cystic fibrosis transmembrane conductance regulator chloride channel. Biophys J 70:743-53

Zhao, J; Zerhusen, B; Xie, J et al. (1996) Rectification of cystic fibrosis transmembrane conductance regulator chloride channel mediated by extracellular divalent cations. Biophys J 71:2458-66

Kelley, T J; Al-Nakkash, L; Cotton, C U et al. (1996) Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition. J Clin Invest 98:513-20

Kelley, T J; al-Nakkash, L; Drumm, M L (1995) CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells. Am J Respir Cell Mol Biol 13:657-64