Acute Phase Regulation of PA-Inhibitor in Human Liver

Gelehrter, Thomas D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK046010-03
• Application #: 2145236
• Study Section: Endocrinology Study Section (END)
• Project Start: 1994-06-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Michigan Ann Arbor
• Department: Genetics
• Type: Schools of Medicine
• DUNS #: 791277940
• City: Ann Arbor
• State: MI
• Country: United States
• Zip Code: 48109

Publications

Seki, T; Healy, A M; Fletcher, D S et al. (1999) IL-1beta mediates induction of hepatic type 1 plasminogen activator inhibitor in response to local tissue injury. Am J Physiol 277:G801-9

Song, C Z; Tian, X; Gelehrter, T D (1999) Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3. Proc Natl Acad Sci U S A 96:11776-81

Song, C Z; Siok, T E; Gelehrter, T D (1998) Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter. J Biol Chem 273:29287-90

Seki, T; Imai, H; Uno, S et al. (1996) Production of tissue-type plasminogen activator (t-PA) and type-1 plasminogen activator inhibitor (PAI-1) in mildly cirrhotic rat liver. Thromb Haemost 75:801-7

Seki, T; Gelehrter, T D (1996) Interleukin-1 induction of type-1 plasminogen activator inhibitor (PAI-1) gene expression in the mouse hepatocyte line, AML 12. J Cell Physiol 168:648-56