Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046272-03
Application #
2145449
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208
Kutz, S M; Providence, K M; Higgins, P J (2001) Antisense targeting of c-fos transcripts inhibits serum- and TGF-beta 1-stimulated PAI-1 gene expression and directed motility in renal epithelial cells. Cell Motil Cytoskeleton 48:163-74
White, L A; Bruzdzinski, C; Kutz, S M et al. (2000) Growth state-dependent binding of USF-1 to a proximal promoter E box element in the rat plasminogen activator inhibitor type 1 gene. Exp Cell Res 260:127-35
Providence, K M; Kutz, S M; Staiano-Coico, L et al. (2000) PAI-1 gene expression is regionally induced in wounded epithelial cell monolayers and required for injury repair. J Cell Physiol 182:269-80
Suzuki, T; Higgins, P J; Crawford, D R (2000) Control selection for RNA quantitation. Biotechniques 29:332-7
Providence, K M; Kutz, S M; Higgins, P J (1999) Perturbation of the actin cytoskeleton induces PAI-1 gene expression in cultured epithelial cells independent of substrate anchorage. Cell Motil Cytoskeleton 42:218-29
Boehm, J R; Kutz, S M; Sage, E H et al. (1999) Growth state-dependent regulation of plasminogen activator inhibitor type-1 gene expression during epithelial cell stimulation by serum and transforming growth factor-beta1. J Cell Physiol 181:96-106
Slack, J K; Higgins, P J (1999) Attenuation of plasminogen activator inhibitor type-1 promoter activity in serum-stimulated renal epithelial cells by a distal 5' flanking region. Cell Motil Cytoskeleton 44:168-76
Higgins, P J; Slack, J K; Diegelmann, R F et al. (1999) Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype. Exp Cell Res 248:634-42
Mu, X C; Staiano-Coico, L; Higgins, P J (1998) Increased transcription and modified growth state-dependent expression of the plasminogen activator inhibitor type-1 gene characterize the senescent phenotype in human diploid fibroblasts. J Cell Physiol 174:90-8
Hawks, K; Higgins, P J (1998) Cell shape-dependent pathway of plasminogen activator inhibitor type-1 gene expression requires cytoskeletal reorganization. J Cell Physiol 176:293-302

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