Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046301-03
Application #
2145484
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-12-15
Project End
1997-11-30
Budget Start
1996-01-25
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Marino, M; Chiovato, L; Lisi, S et al. (2001) Binding of the low density lipoprotein receptor-associated protein (RAP) to thyroglobulin (Tg): putative role of RAP in the Tg secretory pathway. Mol Endocrinol 15:1829-37
Marino, M; Pinchera, A; McCluskey, R T et al. (2001) Megalin in thyroid physiology and pathology. Thyroid 11:47-56
Marino, M; Andrews, D; Brown, D et al. (2001) Transcytosis of retinol-binding protein across renal proximal tubule cells after megalin (gp 330)-mediated endocytosis. J Am Soc Nephrol 12:637-48
Marino, M; McCluskey, R T (2000) Role of thyroglobulin endocytic pathways in the control of thyroid hormone release. Am J Physiol Cell Physiol 279:C1295-306
Marino, M; Zheng, G; Chiovato, L et al. (2000) Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release. J Biol Chem 275:7125-37
Marino, M; Friedlander, J A; McCluskey, R T et al. (1999) Identification of a heparin-binding region of rat thyroglobulin involved in megalin binding. J Biol Chem 274:30377-86
Marino, M; Zheng, G; McCluskey, R T (1999) Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells. J Biol Chem 274:12898-904
Jung, F F; Bachinsky, D R; Tang, S S et al. (1998) Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. Kidney Int 53:358-66
Hellmark, T; Niles, J L; Collins, A B et al. (1997) Comparison of anti-GBM antibodies in sera with or without ANCA. J Am Soc Nephrol 8:376-85
Abbate, M; Bachinsky, D R; McCluskey, R T et al. (1994) Expression of gp330 and gp330/alpha 2-macroglobulin receptor-associated protein in renal tubular differentiation. J Am Soc Nephrol 4:2003-15

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