Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046621-04
Application #
2145873
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1993-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Organized Research Units
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Schloot, N C; Roep, B O; Wegmann, D et al. (1997) Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects. Diabetologia 40:564-72
Lafferty, K J; Gazda, L S (1997) Tolerance: a case of self/not-self discrimination maintained by clonal deletion? Hum Immunol 52:119-26
Calcinaro, F; Gambelunghe, G; Lafferty, K J (1997) Protection from autoimmune diabetes by adjuvant therapy in the non-obese diabetic mouse: the role of interleukin-4 and interleukin-10. Immunol Cell Biol 75:467-71
Gazda, L S; Charlton, B; Lafferty, K J (1997) Diabetes results from a late change in the autoimmune response of NOD mice. J Autoimmun 10:261-70
Gazda, L S; Baxter, A G; Lafferty, K J (1996) Regulation of autoimmune diabetes: characteristics of non-islet-antigen specific therapies. Immunol Cell Biol 74:401-7
Daniel, D; Wegmann, D R (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci U S A 93:956-60
Daniel, D; Gill, R G; Schloot, N et al. (1995) Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 25:1056-62
Wegmann, D R; Gill, R G; Norbury-Glaser, M et al. (1994) Analysis of the spontaneous T cell response to insulin in NOD mice. J Autoimmun 7:833-43
Wegmann, D R; Norbury-Glaser, M; Daniel, D (1994) Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24:1853-7
Shehadeh, N; Calcinaro, F; Bradley, B J et al. (1994) Effect of adjuvant therapy on development of diabetes in mouse and man. Lancet 343:706-7

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