Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046939-04
Application #
2146241
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mishra, Rangnath; Wang, Yuan; Simonson, Michael S (2005) Cell cycle signaling by endothelin-1 requires Src nonreceptor protein tyrosine kinase. Mol Pharmacol 67:2049-56
Mishra, Rangnath; Leahy, Patrick; Simonson, Michael S (2003) Gene expression profile of endothelin-1-induced growth in glomerular mesangial cells. Am J Physiol Cell Physiol 285:C1109-15
Wang, Yuan; Mishra, Rangnath; Simonson, Michael S (2003) Ca2+/calmodulin-dependent protein kinase II stimulates c-fos transcription and DNA synthesis by a Src-based mechanism in glomerular mesangial cells. J Am Soc Nephrol 14:28-36
Simonson, Michael S; Robinson, Ann V; Schulak, James A et al. (2002) Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine. Transplantation 73:1054-9
Mishra, Rangnath; Leahy, Patrick; Simonson, Michael S (2002) Gene expression profiling reveals role for EGF-family ligands in mesangial cell proliferation. Am J Physiol Renal Physiol 283:F1151-9
Chareandee, C; Herman, W H; Hricik, D E et al. (2000) Elevated endothelin-1 in tubular epithelium is associated with renal allograft rejection. Am J Kidney Dis 36:541-9
Simonson, M S; Herman, W H; Robinson, A et al. (1999) Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts. Transplantation 67:1542-7
Simonson, M S; Hricik, D E (1999) Nitric oxide upregulates HLA-DR in human vascular endothelial cells. Transplant Proc 31:737-8
Simonson, M S; Herman, W H; Knauss, T C et al. (1999) Macrophages--but not T-cell--derived cytokines stimulate endothelin-1 secretion by endothelial cells. Transplant Proc 31:806-7
Herman, W H; Holcomb, J M; Hricik, D E et al. (1999) Interleukin-1 beta induces endothelin-1 gene by multiple mechanisms. Transplant Proc 31:1412-3

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