Signaling Properties of the Pth/Pthrp Receptor

Segre, Gino V.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK047034-04
• Application #: 2146351
• Study Section: Orthopedics and Musculoskeletal Study Section (ORTH)
• Project Start: 1993-08-01
• Project End: 1998-07-31
• Budget Start: 1996-09-01
• Budget End: 1997-07-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Ogata, Naoshi; Kawaguchi, Hiroshi; Chung, Ung-il et al. (2007) Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem 282:35757-64

Shimada, Masako; Chen, Xin; Cvrk, Tomas et al. (2002) Purification and characterization of a receptor for human parathyroid hormone and parathyroid hormone-related peptide. J Biol Chem 277:31774-80

Iida-Klein, A; Guo, J; Takemura, M et al. (1997) Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. J Biol Chem 272:6882-9

Offermanns, S; Iida-Klein, A; Segre, G V et al. (1996) G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Mol Endocrinol 10:566-74

Iida-Klein, A; Guo, J; Xie, L Y et al. (1995) Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C. J Biol Chem 270:8458-65

Hayes, G; Forgo, J; Bringhurst, F R et al. (1995) Expression of parathyroid hormone receptors in MDCK and LLC-PK1 cells. Pflugers Arch 430:636-44