Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047168-02
Application #
2146494
Study Section
General Medicine B Study Section (GMB)
Project Start
1995-02-15
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Fiaschi-Taesch, Nathalie M; Santos, Soledad; Reddy, Vasumathi et al. (2004) Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: the efficacy of parathyroid hormone-related protein and hepatocyte growth factor. J Am Soc Nephrol 15:112-25
Garcia-Ocana, Adolfo; Takane, Karen K; Reddy, Vasumathi T et al. (2003) Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 278:343-51
Siddique, Aleem; Malo, Madhu S; Ocuin, Lee M et al. (2003) Convergence of the thyroid hormone and gut-enriched Kruppel-like factor pathways in the context of enterocyte differentiation. J Gastrointest Surg 7:1053-61; discussion 1061
Cebrian, Ana; Garcia-Ocana, Adolfo; Takane, Karen K et al. (2002) Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. Diabetes 51:3003-13
Garcia-Ocana, A; Vasavada, R C; Cebrian, A et al. (2001) Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 50:2752-62
Garcia-Ocana, A; Vasavada, R C; Takane, K K et al. (2001) Using beta-cell growth factors to enhance human pancreatic Islet transplantation. J Clin Endocrinol Metab 86:984-8
Luparello, C; Romanotto, R; Tipa, A et al. (2001) Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells. J Bone Miner Res 16:2173-81
Vasavada, R C; Garcia-Ocana, A; Zawalich, W S et al. (2000) Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem 275:15399-406
Garcia-Ocana, A; Takane, K K; Syed, M A et al. (2000) Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 275:1226-32
Porter, S E; Sorenson, R L; Dann, P et al. (1998) Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. Endocrinology 139:3743-51

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