Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047417-02
Application #
2146996
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1995-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Martinez, Osvaldo; Gangi, Eryn; Mordi, David et al. (2007) Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses. Endocrinology 148:752-61
Gangi, Eryn; Kapatral, Vinayak; El-Azami El-Idrissi, Mohammed et al. (2004) Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity 37:515-20
Singh, Surya P; McDonald, David; Hope, Thomas J et al. (2004) Upon thyrotropin binding the thyrotropin receptor is internalized and localized to endosome. Endocrinology 145:1003-10
Vasu, Chenthamarakshan; Wang, Amy; Gorla, Seema R et al. (2003) CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol 15:167-75
Vasu, Chenthamarakshan; Holterman, Mark J; Prabhakar, Bellur S (2003) Modulation of dendritic cell function and cytokine production to prevent thyroid autoimmunity. Autoimmunity 36:389-96
Vasu, Chenthamarakshan; Dogan, Rukiye-Nazan E; Holterman, Mark J et al. (2003) Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J Immunol 170:5511-22
Prasad, Kanteti V; Prabhakar, Bellur S (2003) Apoptosis and autoimmune disorders. Autoimmunity 36:323-30
Dogan, Rukiye-Nazan E; Vasu, Chenthamarakshan; Holterman, Mark J et al. (2003) Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol 170:2195-204
Cundiff, J G; Kaithamana, S; Seetharamaiah, G S et al. (2001) Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production. J Clin Endocrinol Metab 86:4254-60
Rao, S; Vasu, C; Martinez, O et al. (2001) Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo. Clin Immunol 101:136-45

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