Novel Approach to the Molecular Genetics of PKD1

Agency: National Institute of Health (NIH)
Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type: Research Project (R01)
Project #: 5R01DK048006-03
Application #: 2148010
Study Section: General Medicine B Study Section (GMB)


NIH 2003 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University	$406,188
NIH 2002 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University	$394,594
NIH 2001 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University	$383,293
NIH 2000 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University	$383,471
NIH 1999 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University
NIH 1998 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University
NIH 1997 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University
NIH 1996 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University
NIH 1995 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University
NIH 1994 R01 DK	Novel Approach to the Molecular Genetics of PKD1 Germino, Gregory G. / Johns Hopkins University

Pei, York; Lan, Zheng; Wang, Kairong et al. (2012) A missense mutation in PKD1 attenuates the severity of renal disease. Kidney Int 81:412-7

Steigelman, Katherine A; Lelli, Andrea; Wu, Xudong et al. (2011) Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci 31:12241-50

Shillingford, Jonathan M; Piontek, Klaus B; Germino, Gregory G et al. (2010) Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol 21:489-97

Garcia-Gonzalez, Miguel A; Outeda, Patricia; Zhou, Qin et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS One 5:

Raphael, Kalani L; Strait, Kevin A; Stricklett, Peter K et al. (2009) Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. Kidney Int 75:626-33

Raphael, K L; Strait, K A; Stricklett, P K et al. (2009) Effect of pioglitazone on survival and renal function in a mouse model of polycystic kidney disease. Am J Nephrol 30:468-73

Kottgen, Michael; Buchholz, Bjorn; Garcia-Gonzalez, Miguel A et al. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182:437-47

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