Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048046-03
Application #
2148082
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Horváth, Gerg?; Bencsura, Ákos; Simon, Ágnes et al. (2016) Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. FEBS J 283:541-55
Beck, Moriah R; Dekoster, Gregory T; Cistola, David P et al. (2009) NMR structure of a fungal virulence factor reveals structural homology with mammalian saposin B. Mol Microbiol 72:344-53
Beck, Moriah R; DeKoster, Gregory T; Hambly, David M et al. (2008) Structural features responsible for the biological stability of Histoplasma's virulence factor CBP. Biochemistry 47:4427-38
Toke, Orsolya; Monsey, John D; Cistola, David P (2007) Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis. Biochemistry 46:5427-36
Toke, Orsolya; Monsey, John D; DeKoster, Gregory T et al. (2006) Determinants of cooperativity and site selectivity in human ileal bile acid binding protein. Biochemistry 45:727-37
Ogbay, Benhur; Dekoster, Gregory T; Cistola, David P (2004) The NMR structure of a stable and compact all-beta-sheet variant of intestinal fatty acid-binding protein. Protein Sci 13:1227-37
Tochtrop, Gregory P; DeKoster, Gregory T; Covey, Douglas F et al. (2004) A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. J Am Chem Soc 126:11024-9
Tochtrop, Gregory P; Bruns, Jamie L; Tang, Changguo et al. (2003) Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry 42:11561-7
Tochtrop, Gregory P; DeKoster, Gregory T; Cistola, David P et al. (2002) A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorg Med Chem Lett 12:433-5
Tochtrop, Gregory P; Richter, Klaus; Tang, Changguo et al. (2002) Energetics by NMR: site-specific binding in a positively cooperative system. Proc Natl Acad Sci U S A 99:1847-52

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