Hematopoietic Stem Cells - Mechanisms of Self Replication

Bartelmez, Stephen Hollis

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK048708-04
• Application #: 2016864
• Study Section: Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
• Project Start: 1994-09-16
• Project End: 1998-08-31
• Budget Start: 1996-09-18
• Budget End: 1997-08-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Seattle Biomedical Research Institute
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98109

Publications

Hazra, Sugata; Stepps, Valerie; Bhatwadekar, Ashay D et al. (2013) Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1. PLoS One 8:e79067

Tsai, S; Fero, J; Bartelmez, S (2000) Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96:950-7

Ritchie, K A; Aprikyan, A A; Bowen-Pope, D F et al. (1999) The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice. Leukemia 13:1790-803

Yagi, M; Ritchie, K A; Sitnicka, E et al. (1999) Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proc Natl Acad Sci U S A 96:8126-31

Sitnicka, E; Ruscetti, F W; Priestley, G V et al. (1996) Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells. Blood 88:82-8