Exercise, Denervation and Insulin Resistance in Muscle

Ruderman, Neil B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 1R01DK049147-01A2
• Application #: 2149768
• Study Section: Respiratory and Applied Physiology Study Section (RAP)
• Project Start: 1996-08-01
• Project End: 2001-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Boston Medical Center
• DUNS #: 005492160
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02118

Publications

LeBrasseur, Nathan K; Kelly, Meghan; Tsao, Tsu-Shuen et al. (2006) Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab 291:E175-81

Nawrocki, Andrea R; Rajala, Michael W; Tomas, Eva et al. (2006) Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 281:2654-60

Kuhl, Jeanette E; Ruderman, Neil B; Musi, Nicolas et al. (2006) Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab 290:E1296-303

Suchankova, Gabriela; Tekle, Michael; Saha, Asish K et al. (2005) Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem Biophys Res Commun 326:851-8

Hosaka, Toshio; Brooks, Cydney C; Presman, Eleonora et al. (2005) p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation. Mol Biol Cell 16:2882-90

Yu, X; McCorkle, S; Wang, M et al. (2004) Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 47:2012-21

Ruderman, N B; Cacicedo, J M; Itani, S et al. (2003) Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans 31:202-6

Itani, Samar I; Saha, Asish K; Kurowski, Theodore G et al. (2003) Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes 52:1635-40

Tortorella, Lori L; Lin, Connie B; Pilch, Paul F (2003) ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle. Biochem Biophys Res Commun 306:163-8

Ruderman, N B; Park, H; Kaushik, V K et al. (2003) AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol Scand 178:435-42