Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049516-03
Application #
2016958
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-09-30
Project End
1999-08-31
Budget Start
1996-09-20
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Singh, D K; McCormick, C; Pacyniak, E et al. (2001) A simian human immunodeficiency virus with a nonfunctional Vpu (deltavpuSHIV(KU-1bMC33)) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype. Virology 282:123-40
Stephens, E B; Singh, D K; Pacyniak, E et al. (2001) Comparison of Vif sequences from diverse geographical isolates of HIV type 1 and SIV(cpz) identifies substitutions common to subtype C isolates and extensive variation in a proposed nuclear transport inhibition signal. AIDS Res Hum Retroviruses 17:169-77
McCormick-Davis, C; Dalton, S B; Hout, D R et al. (2000) A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques. Virology 272:112-26
McCormick-Davis, C; Dalton, S B; Singh, D K et al. (2000) Comparison of Vpu sequences from diverse geographical isolates of HIV type 1 identifies the presence of highly variable domains, additional invariant amino acids, and a signature sequence motif common to subtype C isolates. AIDS Res Hum Retroviruses 16:1089-95
Stephens, E B; Tian, C; Dalton, S B et al. (2000) Simian-human immunodeficiency virus-associated nephropathy in macaques. AIDS Res Hum Retroviruses 16:1295-306
Liu, Z Q; Muhkerjee, S; Sahni, M et al. (1999) Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques. Virology 260:295-307
Zhuge, W; Jia, F; Stephens, E B et al. (1998) Failure of SIVmac to be neutralized in macrophage cultures is unique to SIVmac and not observed with neutralization of SHIV or HIV-1. AIDS Res Hum Retroviruses 14:1045-51
McCormick-Davis, C; Zhao, L J; Mukherjee, S et al. (1998) Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques. Virology 248:275-83
Gattone 2nd, V H; Tian, C; Zhuge, W et al. (1998) SIV-associated nephropathy in rhesus macaques infected with lymphocyte-tropic SIVmac239. AIDS Res Hum Retroviruses 14:1163-80
Stephens, E B; Tian, C; Li, Z et al. (1998) Rhesus macaques infected with macrophage-tropic simian immunodeficiency virus (SIVmacR71/17E) exhibit extensive focal segmental and global glomerulosclerosis. J Virol 72:8820-32

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