Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049615-01A1
Application #
2150441
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Specht, Susan; Isse, Kumiko; Nozaki, Isao et al. (2013) SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis 30:877-90
Demetris, Anthony J; Specht, Susan; Nozaki, Isao et al. (2008) Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. J Hepatol 48:276-88
Lim, Kyu; Han, Chang; Xu, Lihong et al. (2008) Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res 68:553-60
Lunz 3rd, John G; Specht, Susan M; Murase, Noriko et al. (2007) Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology 46:1946-59
Demetris, Anthony J; Kelly, Dympna M; Eghtesad, Bijan et al. (2006) Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. Am J Surg Pathol 30:986-93
Demetris, A J; Fontes, Paulo; Lunz 3rd, John G et al. (2006) Wound healing in the biliary tree of liver allografts. Cell Transplant 15 Suppl 1:S57-65
Demetris, A-J; Lunz 3rd, John-G; Specht, Susan et al. (2006) Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. World J Gastroenterol 12:3512-22
Han, Chang; Demetris, A Jake; Stolz, Donna B et al. (2006) Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway. J Biol Chem 281:24831-46
Toyokawa, Hideyoshi; Nakao, Atsunori; Stolz, Donna B et al. (2006) 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injury. Lab Invest 86:72-82
Nozaki, Isao; Lunz 3rd, John G; Specht, Susan et al. (2005) Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. Lab Invest 85:109-23

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