Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049629-01A2
Application #
2150468
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1996-08-01
Project End
2001-06-30
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Genetics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

DeAngelis, Robert A; Markiewski, Maciej M; Taub, Rebecca et al. (2005) A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42:1148-57
Bansal, Meena B; Kovalovich, Kellen; Gupta, Ritu et al. (2005) Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol 42:548-56
Leu, Julia I; Crissey, Mary Ann S; Craig, Linden E et al. (2003) Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Mol Cell Biol 23:1251-9
Macias-Silva, Marina; Li, Wei; Leu, Julia I et al. (2002) Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J Biol Chem 277:28483-90
DeAngelis, R A; Kovalovich, K; Cressman, D E et al. (2001) Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice. Hepatology 33:915-24
Kovalovich, K; Li, W; DeAngelis, R et al. (2001) Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem 276:26605-13
Li, W; Liang, X; Leu, J I et al. (2001) Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy. Hepatology 33:1377-86
Kovalovich, K; DeAngelis, R A; Li, W et al. (2000) Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 31:149-59
Taub, R; Greenbaum, L E; Peng, Y (1999) Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis 19:117-27
Crissey, M A; Leu, J I; De Angelis, R A et al. (1999) Liver-specific and proliferation-induced deoxyribonuclease I hypersensitive sites in the mouse insulin-like growth factor binding protein-1 gene. Hepatology 30:1187-97

Showing the most recent 10 out of 14 publications