Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049652-03
Application #
2150505
Study Section
Special Emphasis Panel (ZHL1-CSR-K (M1))
Project Start
1994-09-30
Project End
1998-08-31
Budget Start
1996-09-09
Budget End
1998-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Abkowitz, Janis L; Sabo, Kathleen M; Yang, Zhantao et al. (2009) In utero transplantation of monocytic cells in cats with alpha-mannosidosis. Transplantation 88:323-9
Ellinwood, N Matthew; Vite, Charles H; Haskins, Mark E (2004) Gene therapy for lysosomal storage diseases: the lessons and promise of animal models. J Gene Med 6:481-506
Vite, Charles H; Passini, Marco A; Haskins, Mark E et al. (2003) Adeno-associated virus vector-mediated transduction in the cat brain. Gene Ther 10:1874-81
Vite, C H; McGowan, J C; Braund, K G et al. (2001) Histopathology, electrodiagnostic testing, and magnetic resonance imaging show significant peripheral and central nervous system myelin abnormalities in the cat model of alpha-mannosidosis. J Neuropathol Exp Neurol 60:817-28
Sun, H; Yang, M; Haskins, M E et al. (1999) Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts. Hum Gene Ther 10:1311-9
Kennedy, D W; Abkowitz, J L (1998) Mature monocytic cells enter tissues and engraft. Proc Natl Acad Sci U S A 95:14944-9
Abkowitz, J L; Taboada, M R; Sabo, K M et al. (1998) The ex vivo expansion of feline marrow cells leads to increased numbers of BFU-E and CFU-GM but a loss of reconstituting ability. Stem Cells 16:288-93
Kennedy, D W; Abkowitz, J L (1997) Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90:986-93