Nutrition, Cytokines, and Anabolic Signaling Mechanisms

Smith, Robert J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK050411-02
• Application #: 2151424
• Study Section: Special Emphasis Panel (ZRG4-NTN (06))
• Project Start: 1995-09-01
• Project End: 1999-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Joslin Diabetes Center
• DUNS #: 071723084
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02215

Publications

Ling, Pei-Ra; Smith, Robert J; Bistrian, Bruce R (2007) Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats. Crit Care Med 35:555-60

Dufresne, Aimee M; Smith, Robert J (2005) The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling. Endocrinology 146:4399-409

Ling, Pei-Ra; Smith, Robert J; Bistrian, Bruce R (2005) Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats. Crit Care Med 33:1084-9

Ling, Pei-Ra; Smith, Robert J; Kie, Susanne et al. (2004) Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats. Am J Physiol Regul Integr Comp Physiol 287:R801-8

Ling, Pei-Ra; Mueller, Claudia; Smith, Robert J et al. (2003) Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats. Metabolism 52:868-74

Ling, Pei-Ra; Smith, Robert J; Mueller, Claudia et al. (2002) Inhibition of interleukin-6-activated janus kinases/signal transducers and activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats. Crit Care Med 30:202-11

McCowen, K C; Ling, P R; Ciccarone, A et al. (2001) Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade. Crit Care Med 29:839-46

Ling, P R; Lydon, E; Qu, Z et al. (2000) Metabolic effects of insulin and insulin-like growth factor-I in endotoxemic rats during total parenteral nutrition feeding. Metabolism 49:611-5

Mao, Y; Ling, P R; Fitzgibbons, T P et al. (1999) Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo. Endocrinology 140:5505-15

McCowen, K C; Chow, J C; Smith, R J (1998) Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 139:4442-7