Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050550-09
Application #
6524174
Study Section
Special Emphasis Panel (ZRG1-AARR-2 (01))
Program Officer
Hamilton, Frank A
Project Start
1995-09-30
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
9
Fiscal Year
2002
Total Cost
$468,334
Indirect Cost

  Institution

Name
Tulane University
Department
Type
Other Domestic Higher Education
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

Mohan, Mahesh; Kaushal, Deepak; Aye, Pyone P et al. (2013) Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection. PLoS One 8:e60122
Mohan, Mahesh; Kaushal, Deepak; Aye, Pyone P et al. (2012) Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction. PLoS One 7:e34561
Lackner, Andrew A; Mohan, Mahesh; Veazey, Ronald S (2009) The gastrointestinal tract and AIDS pathogenesis. Gastroenterology 136:1965-78
Mohan, Mahesh; Aye, Pyone P; Borda, Juan T et al. (2008) CCAAT/enhancer binding protein beta is a major mediator of inflammation and viral replication in the gastrointestinal tract of simian immunodeficiency virus-infected rhesus macaques. Am J Pathol 173:106-18
Garza, A; Lackner, A; Aye, P et al. (2008) Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol 37:109-15
Mohan, Mahesh; Aye, Pyone P; Borda, Juan T et al. (2007) Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway. Am J Pathol 171:1952-65
Hernandez, Julio; Lackner, Andrew; Aye, Pyone et al. (2007) Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun 75:1137-43
Ramesh, Geeta; Alvarez, Xavier; Borda, Juan T et al. (2005) Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation. Clin Diagn Lab Immunol 12:192-7
Freeman, Lisa M; Mansfield, Keith G; Goldin, Barry et al. (2004) Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaque. J Infect Dis 189:2010-5
Yang, Gui-Bo; Lackner, Andrew A (2004) Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity. J Neuroimmunol 146:46-9

Showing the most recent 10 out of 35 publications