Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK050780-02
Application #
2701198
Study Section
Special Emphasis Panel (ZRG4-GMB (04))
Project Start
1997-05-01
Project End
2002-04-30
Budget Start
1997-09-01
Budget End
1998-04-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Mak, Robert H; Cheung, Wai W; Gertler, Arieh (2014) Exploiting the therapeutic potential of leptin signaling in cachexia. Curr Opin Support Palliat Care 8:352-7
Mak, Robert H; Cheung, Wai W; Roberts Jr, Charles T (2008) The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res 18:17-25
Mak, Robert H; Cheung, Wai (2007) Adipokines and gut hormones in end-stage renal disease. Perit Dial Int 27 Suppl 2:S298-302
Cheung, Wai W; Kuo, Huey-Ju; Markison, Stacy et al. (2007) Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol 18:2517-24
Mak, Robert H; Cheung, Wai (2007) Cachexia in chronic kidney disease: role of inflammation and neuropeptide signaling. Curr Opin Nephrol Hypertens 16:27-31
Mak, Robert H; Cheung, Wai; Purnell, Jonathan (2007) Ghrelin in chronic kidney disease: too much or too little? Perit Dial Int 27:51-5
Mak, Robert H; Cheung, Wai; Cone, Roger D et al. (2006) Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia. Nat Clin Pract Nephrol 2:527-34
Murray, J F; Hahn, J D; Kennedy, A R et al. (2006) Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. J Neuroendocrinol 18:157-67
Mak, R H; Cheung, W; Cone, R D et al. (2006) Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69:794-7
Cheung, Wai; Yu, Pin X; Little, Brian M et al. (2005) Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115:1659-65

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